https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16751 Wed 11 Apr 2018 16:36:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24162 Wed 11 Apr 2018 11:25:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29973 2). The blood levels of CsA (Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay (EMIT) on Cobas Mira. Statistical analyses of interactions were done by an accelerated failure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity. Results: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and CsA in the prolongation of cardiac allograft survival for dose ranges of CsA by castanospermine of (0 to 2) mg/kg by (0 to 200) mg/kg (HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and (0 to 3) mg/kg by (0 to 100) mg/kg (HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of CsA. On the contrary, cessation of castanospermine in the presence of CsA at 2 mg/kg significantly increased the CsA level (P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. Conclusion: There is synergistic interaction between castanospermine and CsA in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of CsA provides an explanation.]]> Wed 11 Apr 2018 11:17:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21149 Sat 24 Mar 2018 08:00:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27391 Sat 24 Mar 2018 07:34:10 AEDT ]]>